Med-psych drug-drug interactions update.
نویسندگان
چکیده
Triptans are potent serotonin (5-HT) 1B/1D receptor agonists used to abort and treat migraine headaches. Although the triptans share pharmacodynamic characteristics at 5-HT1B/1D receptors, they differ pharmacokinetically. This coulmn reviews how the triptans are metabolized. Generally, the triptans are metabolized by phase I monoamine oxidases (MAOs) and by various cytochrome P450 enzymes. However, each triptan has a unique metabolic profile, leading to significant differences in each triptan’s potential for drug-drug interactions. These differences are detailed in this review. (Psychosomatics 2002; 43:502–504)
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عنوان ژورنال:
- Psychosomatics
دوره 42 5 شماره
صفحات -
تاریخ انتشار 2001